Can We Trust Safety of Tenofovir Disoproxil in Patients with Decompensated Cirrhosis?
نویسندگان
چکیده
منابع مشابه
Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis
AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate (TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosi...
متن کاملMeta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis.
BACKGROUND The optimal oral anti-viral agent to use in patients with decompensated HBV cirrhosis remains unclear. AIM We performed a meta-analysis of the oral nucleos(t)ide analogues in patients with decompensated HBV cirrhosis. METHODS One year efficacy and safety outcomes in 22 studies published in English between '95 and 2010 were analysed. RESULTS Substantial heterogeneity was noted i...
متن کاملEffects of Entecavir and Tenofovir on Renal Function in Patients with Hepatitis B Virus-Related Compensated and Decompensated Cirrhosis
Background/Aims The renal effects of nucleos(t)ide analogs in patients with chronic hepatitis B are controversial. We aimed to compare the impact of entecavir (ETV) and tenofovir (TDF) on renal function in patients with hepatitis B virus (HBV)-related cirrhosis. Methods We performed a retrospective cohort study of 235 consecutive treatment-naïve patients with HBV-related cirrhosis who were tr...
متن کاملRecent Advances in the Management of Chronic Hepatitis B
There are seven approved treatments for adults with chronic hepatitis B virus infection in the United States and European countries: interferon-α, pegylated interferon-α, lamivudine, adefovir dipivoxil, entecavir, telbivudine, and tenofovir disoproxil fumarate. At present, two new analogues, entecavir and tenofovir are recommended as the first line therapy by the guidelines of European Associat...
متن کاملFatal lactic acidosis in hepatitis B virus-associated decompensated cirrhosis treated with tenofovir
RATIONALE Recently tenofovir disoproxil fumarate (TDF) has been widely used as a first-line therapy for chronic hepatitis B (CHB) infection. Although TDF demonstrates successful viral suppression, the possibility of renal failure and lactic acidosis has been proposed with TDF administration, especially in human immunodeficiency virus co-infected patients. However, TDF induced lactic acidosis ha...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2017